Pome-Bio Prebiotic (60 capsules)

Understanding Prebiotics

Prebiotics act as nourishment for beneficial gut bacteria, such as lactobacilli and bifidobacteria, and promote their growth. Common prebiotics include inulin, fructooligosaccharides, and galactooligosaccharides. Foods rich in prebiotics include garlic, onions, leeks, asparagus, seaweed, burdock root, flaxseed, konjac, apples, unripe bananas, beans, almonds, and whole grain oats. Consuming prebiotics helps increase the population of beneficial gut bacteria, leading to a healthier intestinal environment.

Potential Health Benefits of Prebiotics

• Improved intestinal health:

Prebiotics support the growth and activity of beneficial gut bacteria, promoting a balanced intestinal microbiome.

• Immune system support:

Beneficial bacteria metabolize prebiotics into short-chain fatty acids, such as butyric acid, which contribute to immune system support and a balanced inflammatory response.

• Reduced risk of lifestyle-related diseases:

Studies suggest that a diet rich in prebiotics may lower the risk of diabetes, heart disease, and colon cancer through the production of short-chain fatty acids.

• Enhanced digestion:

Prebiotics may help regulate bowel movements, improve nutrient absorption, and support healthy bowel function.

• Healthy weight management:

Prebiotics can help reduce hunger and increase satiety, aiding in weight management efforts.

Potential Downsides of Prebiotics

Fiber-based prebiotics like inulin, fructooligosaccharides, and galactooligosaccharides can cause gas production and flatulence. In individuals with Small Intestinal Bacterial Overgrowth (SIBO), fermentation can occur in the small intestine, leading to gas accumulation and exacerbated bloating. For such individuals, bioflavonoid-based prebiotics is recommended.

Bioflavonoid-Based Prebiotics: A Solution for Fiber-Based Prebiotic Concerns

Polyphenols, particularly bioflavonoid-based prebiotics, are a suitable alternative for those with SIBO or prone to gas accumulation. Effective polyphenols include punicalagin (found in pomegranates), hesperidin and naringin (found in citrus fruits), quercetin (found in various vegetables), and rutin (found in buckwheat). These prebiotics help increase the population of lactobacilli and bifidobacteria while also promoting the production of short-chain fatty acids. Additionally, bioflavonoid prebiotics has been shown to inhibit the growth of harmful bacteria. Incorporating more pomegranates and citrus fruits into your diet can help regulate gut flora for those who have difficulty tolerating fiber-rich foods.

Pome-Bio Prebiotic Ingredient and Benefits

[Pomanox® Pomegranate Fruit Extract]

Pomanox® is a pomegranate fruit extract that contains polyphenols such as ellagic acid and punicalagin. These compounds help maintain a normal antioxidant and inflammatory balance, supporting overall health. Clinical studies have shown that these polyphenols promote the growth of beneficial intestinal microorganisms. When not fully absorbed in the small intestine, these polyphenols are metabolized by microorganisms into beneficial substances like urolithin.

[The health benefits of urolithin include]

• Improved Mitochondrial Function:

Urolithin activates a pathway called mitophagy, helping to eliminate damaged mitochondria and improve overall mitochondrial function.

• Healthy Inflammatory Balance:

Urolithin supports a healthy inflammatory balance in the body.

• Anti-Aging Effects:

Animal studies suggest that urolithin has anti-aging properties and may extend lifespan by up to 45% in some animals.

• Improved Muscle Function:

Urolithin has been shown in animal studies to improve muscle function and reduce muscle wasting.

[Beauty Advantages of Pomegranate]

Pomegranates, originating from the Middle East, are sometimes called the "fruit of beauty" or the "fruit of paradise" due to their numerous beauty benefits. They are rich in antioxidants, vitamins, and minerals, offering support for skin and hair health. Pomegranates have several beauty-enhancing properties, including:

• Anti-Aging Benefits:

Pomegranates contain antioxidants like ellagic acid and punicalagin, which help protect against oxidative stress and reduce signs of aging.

• Skin Moisturizer:

Pomegranate contains punicic acid, which moisturizes the skin, making it soft and elastic.

• Acne Prevention:

Pomegranate has anti-inflammatory properties that help prevent and improve acne by reducing skin inflammation and irritation.

• Sun Protection:

Pomegranate extract has photoprotective properties, protecting the skin from UV damage and reducing the risk of sunburn.

• Hair Health:

Pomegranate extract promotes hair health due to its high vitamin and mineral content, including vitamin C, vitamin K, and potassium.

[MicrobiomeX® Citrus Bioflavonoid Complex]

The MicrobiomeX® citrus bioflavonoid complex supports gut health by interacting with dietary fiber and polyphenols in food. Gut bacteria can break down polyphenols to produce beneficial components, while polyphenols can affect the quantity and diversity of gut bacteria. Studies have shown that taking 500 mg of citrus fruit extract over three weeks increased the number of butyrate-producing bacteria in the gut. Another study found that taking the MicrobiomeX® citrus bioflavonoid complex increased short-chain fatty acid levels in the gut, which serve as a source of nutrients for intestinal cells. Furthermore, MicrobiomeX® has been reported to support a healthy inflammatory balance. These studies demonstrate that citrus bioflavonoids enhance gut health by increasing the quantity of healthy bacteria and short-chain fatty acids in the intestine.

Pome-Bio Prebiotic's Unique Formulation

Naturopathy's Pome-Bio Prebiotic features a unique blend of Pomanox® and MicrobiomeX®, offering an innovative approach to gut health and overall well-being. This powerful combination provides a range of benefits, including support for the immune system, weight management, and beauty advantages.

• Pomanox® Pomegranate Fruit Extract

The patented Pomanox® is sourced from the Spanish company Euromed and is produced from fresh pomegranate fruit harvested on organic farms under their control to ensure consistent quality and safety. The proprietary Pure-Hydro™ process utilizes water and osmotic water technology to create an eco-friendly, safe, and high-quality product without the use of chemicals. This process also prevents contamination from alkaloids and other contaminants. Pomanox® contains a high concentration of punicalagin, the most important active ingredient in pomegranate, which is largely metabolized by beneficial intestinal bacteria in the small intestine into smaller molecules like ellagic acid and urolithin.

• MicrobiomeX® Citrus Bioflavonoid Complex:

Developed by BioActor of the Netherlands, MicrobiomeX® is a unique complex of hesperidin and naringin. Clinical studies have demonstrated its ability to improve healthy intestinal bacteria, intestinal barrier function, and support a healthy inflammatory balance.

• Quality Assurance and Safety:

Naturopathy's Pome-Bio Prebiotic is manufactured in a facility that adheres to strict quality control measures, following GMP and ISO9001:2008 safety standards. The product undergoes thorough inspections for quality control, active ingredient content, bacteria, stability, residual concentration of chemical solvents, aflatoxins, pesticides, herbicides, fungicides, rancidity, PCBs, dioxins, and more. Additionally, a third party conducts safety inspections for each lot to ensure the quality of raw materials and finished products.

By combining the benefits of Pomanox® Pomegranate Fruit Extract and MicrobiomeX® Citrus Bioflavonoid Complex, Naturopathy's Pome-Bio Prebiotic offers a comprehensive solution to support gut health, immunity, weight management, and overall well-being.

Made in USA.

Suggested use

2 capsules per day

Ingredients

2 Capsules

• Calories 5
• Total Carbohydrate 1 g
• Dietary Fiber, less than 1 g
• Pomegranate Fruit Extract (Pomanox®) [Standardized to contain 30% Total
• Punicalagins (A & B) and Punicalins (A & B)] 500 mg
• Citrus Bioflavonoid Complex (MicrobiomeX®) 500 mg

Other ingredients: Microcrystalline Cellulose, Hypromellose (Natural GASTROINTESTINAL Vegetable Capsules), Magnesium Stearate, Silicon Dioxide

* Contains no: Eggs, dairy products, animal products, corn, soy, fish, crustaceans, nuts, peanuts, flour, gluten, sugar, yeast, artificial colors, and flavors.

Dr. Ozawa makes only supplements that can deliver safety and results. Products that do not pass strict inspection standards for raw materials and products will not be shipped. For this reason, manufacturing may delay. We appreciate your understanding.

References

Euromed Nature & Science. In vitro Studies on the Bifidogeniceffect of Pomanox. Bialonska D, Ramnani P, Kasimsetty SG, Muntha KR, Gibson　GR, Ferreira D. The influence of pomegranate by-productand punicalagins on selected groups of human intestinalmicrobiota. Int J Food Microbiol. 2010;140(2-3):175-182. Euromed Nature & Science. Prebiotic effect of Pomanox™ in　an animal model. Euromed Nature & Science. The Prebiotic Effect of Pomanox™: Clinical Study. Euromed Nature & Science. The Prebiotic Effect of Pomanox™ Clinical Study. Li Z, Henning SM, Lee RP, et al. Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers. Food Funct.2015;6(8):2487-2495. Makki K, Deehan EC, Walter J, Bäckhed F. The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease. Cell host & microbe. 2018;23(6):705-715. Duda-Chodak A, Tarko T, Satora P, Sroka P. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European journal of nutrition. 2015;54(3):325-341. Vamanu E, Gatea F. Correlations between Microbiota Bioactivity and Bioavailability of Functional Compounds: A Mini-Review. Biomedicines. 2020;8(2). Stevens Y, Rymenant EV, Grootaert C, et al. The Intestinal Fate of Citrus Flavanones and Their Effects on Gastrointestinal Health. Nutrients. 2019;11(7). Van Rymenant E, Salden B, Voorspoels S, et al. A Critical Evaluation of In Vitro Hesperidin 2S Bioavailability in a Model Combining Luminal (Microbial) Digestion and Caco-2 Cell Absorption in Comparison to a Randomized Controlled Human Trial. Molecular nutrition & food research.2018;62(8):e1700881. Salden BN, Troost, F.J., Possemiers, S., Stevens, Y., Masclee, A.A.,. In: Maastricht University; 2019.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.