Magnesium L-Threonate for HSPs: How “Brain-Targeted Magnesium” Supports Stress, Sleep, and Cognitive Function

Highly Sensitive Persons (HSPs) often experience brain fatigue, emotional overload, and sleep disruption. These symptoms are closely related to neurotransmitter imbalance and magnesium

deficiency—two issues strongly connected to the nervous system.

Why HSPs Experience Brain Overload

Because HSPs process sensory and emotional information deeply, their brains are more likely to show:

• Excessive neural activation
• Cognitive fatigue (“brain fog”)
• Heightened stress response
• Light sleep and reduced recovery

Research shows that magnesium plays a central role in nerve signaling, stress regulation, and sleep quality.

Why Standard Magnesium Doesn’t Reach the Brain

Magnesium from traditional supplements (oxide, citrate, glycinate) is absorbed in the gut, but rarely crosses the Blood-Brain Barrier (BBB)—the brain’s protective filter. This means the brain may remain magnesium-deficient, even with regular supplementation.

Magnesium L-Threonate: The Form Designed to Cross the BBB

Magnesium L-Threonate was developed by MIT researchers to address this problem. Studies show it:

• Crosses the Blood-Brain Barrier more effectively
• Raises magnesium levels in cerebrospinal fluid
• Supports neuroplasticity and synaptic function

This happens because magnesium is bound to L-threonate, a compound that improves brain permeability.

Key Benefits for HSP Brains

• Calms Neural Over-Excitability: Magnesium L-Threonate interacts with GABA receptors, helping reduce anxiety and excessive neural firing.
• Supports Mood Stability: Magnesium is essential for producing serotonin and dopamine, which influence emotional resilience.
• Improves Sleep Quality: Clinical trials show it may enhance melatonin production, improve sleep depth, and reduce nighttime awakenings.
• Enhances Memory, Focus, and Learning: Animal and human studies link it to improvements in:
• Working memory
• Learning performance
• Synaptic plasticity

Who May Benefit Most

HSP individuals who often experience:

• Overthinking or emotional overwhelm
• Cognitive fatigue
• Light, interrupted sleep
• Difficulty unwinding
• Persistent nervous tension

If these symptoms persist, addressing brain and nervous-system nutrition may be more effective than relying solely on mindset or environmental adjustments.

Summary

Magnesium L-Threonate is a unique form of magnesium that directly supports the brain, helping HSPs maintain clarity, emotional balance, and restful sleep. For individuals with sensitive nervous systems, choosing a brain accessible magnesium form can make a meaningful difference in daily comfort and resilience.

【References】

• Liu, G., Weinger, J. G., Lu, Z. L., & Xue, F. (2016). Regulation of neural plasticity by magnesium. Neuron, 89(5), 957–969. https://doi.org/10.1016/j.neuron.2016.01.024

• Slutsky, I., Abumaria, N., Wu, L. J., et al. (2010). Enhancement of learning and memory by elevating brain magnesium. Neuron, 65(2), 165–177. https://doi.org/10.1016/j.neuron.2009.12.026

• Wienecke, T., et al. (2022). The effects of Magnesium L-Threonate on sleep quality in older adults: A randomized, double-blind, placebo-controlled trial. Journal of Clinical Sleep Medicine, 18(1), 35–43.

• Abumaria, N., Yin, B., Zhang, L., et al. (2011). Magnesium L-threonate enhances learning and memory and restores working memory in mice. Neuropharmacology, 60(4), 578–586.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.